••Hot Topics: Pulmonary Circulation and HAPE•• PULMONARY BLOOD FLOW HETEROGENEITY DURING HY- POXIA IN SUBJECTS WITH A HISTORY OF HIGH ALTITUDE PUL- MONARY EDEMA (HAPE)
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Hypoxia-induced pulmonary blood redistribution in subjects with a history of high-altitude pulmonary edema.
BACKGROUND Pulmonary hypertension has been suggested to play an important role in development of high-altitude pulmonary edema (HAPE), and individual susceptibility has been suggested to be associated with enhanced pulmonary vascular response to hypoxia. We hypothesized that much greater pulmonary vasoconstriction would be induced by acute alveolar hypoxia in HAPE-susceptible (HAPE-s) subjects ...
متن کاملEvidence supportive of impaired myocardial blood flow reserve at high altitude in subjects developing high-altitude pulmonary edema.
An exaggerated increase in pulmonary arterial pressure is the hallmark of high-altitude pulmonary edema (HAPE) and is associated with endothelial dysfunction of the pulmonary vasculature. Whether the myocardial circulation is affected as well is not known. The aim of this study was, therefore, to investigate whether myocardial blood flow reserve (MBFr) is altered in mountaineers developing HAPE...
متن کاملHigh-altitude pulmonary edema is initially caused by an increase in capillary pressure.
BACKGROUND High-altitude pulmonary edema (HAPE) is characterized by severe pulmonary hypertension and bronchoalveolar lavage fluid changes indicative of inflammation. It is not known, however, whether the primary event is an increase in pressure or an increase in permeability of the pulmonary capillaries. METHODS AND RESULTS We studied pulmonary hemodynamics, including capillary pressure dete...
متن کاملAssociation of high-altitude pulmonary edema with the major histocompatibility complex.
BACKGROUND A constitutional susceptibility has been suggested in the development of high-altitude pulmonary edema (HAPE) because HAPE generally affects healthy young people, some of whom suffer recurrent episodes. We examined whether immunogenetic susceptibility is present in HAPE-susceptible subjects. METHODS AND RESULTS The frequencies of human leukocyte antigen (HLA) alleles in 28 male and...
متن کاملHypoxia impairs systemic endothelial function in individuals prone to high-altitude pulmonary edema.
RATIONALE High-altitude pulmonary edema (HAPE) is characterized by excessive pulmonary vasoconstriction and is associated with decreased concentrations of nitric oxide (NO) in the lung. OBJECTIVES We hypothesized that individuals susceptible to HAPE (HAPE-S) would also have dysfunction of the vascular NO vasodilator pathway during hypoxia in the systemic vasculature. METHODS During normoxia...
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